A manifest of our clinical trials

Explore the studies powered by Spiral’s trial infrastructure, from adaptive ICU trials and global multi-centre studies to clinic and community-based research.

Intensive Care

Where complex protocols meet real clinical conditions.

  • REMAP-CAP

    REMAP-CAP: Severe Community Acquired Pneumonia (severe CAP) is a major cause of mortality

  • MEGA-ROX

    MEGA-ROX: Multicentre, multinational, randomised clinical trial to comapring conservative oxygen therapy with usual oxygen therapy in mechanically ventilated patients.

  • PLATIPUS

    PLATIPUS: Assess medicines and therapies in pregnancies at risk of preterm birth (birth before 37 weeks of gestation), and in babies born preterm.

  • STEPCARE

    STEPCARE: Aims to determine the optimal intensive care treatment for patients after arrival in hospital.

  • REDUSE

    REDUSE: Integrating research for human-centred treatment in septic shock.

  • ASCOT

    ASCOT: A clinical trial that will generate clinical evidence on treatment for COVID-19, which can be applied during a pandemic to reduce mortality.

  • TTM2

    TTM2: This trial is a phase III, multi-centre, randomised, parallel-group, clinical trial in resuscitated cardiac arrest patients admitted to the intensive care unit.

Hospital Wards

Hospital-based, inpatient or specialist ward-focused studies outside ICU protocols.

  • SNAP

    SNAP: Aims to improve treatment outcomes for patients with Staphylococcus aureus bloodstream infections.

  • CAPTIVATE

    CAPTIVATE: The Global Kidney Patient Trials Network (GKPTN) registry has enrolled 4334 patients with chronic kidney disease since May 2020 across 119 sites in 8 countries.

  • ROADMAP

    ROADMAP: Prosthetic joint infections (PJI) affect ~1–3% of hip and knee replacements and are difficult to treat due to bacterial biofilms on implants.

Clinic-Based

Outpatient, specialist, clinic, or follow-up-style environments.

  • STOP-KNEE-OA

    STOP-KNEE-OA: Subcutaneous Tirzepatide nce-weekly in Patients With Obesity and Knee Osteoarthritis

  • T1D PLUS

    T1D PLUS: This trial involves 40 sites across Europe, including the UK, Austria, France, Belgium, Germany, and Italy. 

Community-Based

Remote participation, primary care, home monitoring, or distributed community recruitment.

  • PANORAMIC

    PANORAMIC: identify treatments for Covid-19 for use in the community early on in the illness that speeds recovery and prevents the need for hospital admission.

  • REST

    REST: a multi-arm digital sleep intervention trial targeting adolescents aged 12–16 years and their parents or caregivers.

  • WHAKAMOEARIKI

    WHAKAMOEARIKI: a Māori-led, kaupapa Māori-aligned randomised study centred on Māori women and their whānau.

BLOG:PLATIPUS

A neonatal trial that spans hospital and intensive care

One of the trials currently preparing to go live at Spiral is PLATIPUS, an Australasian platform trial led out of the University of Melbourne, focused on improving outcomes for babies at risk of preterm birth, or born preterm.

Receive Spiral Stories

Insights, trial updates, and design thinking from across ICU, wards, clinics, and community-based studies.