The heart
of our software innovation

Improve the ethical and scientific quality of your clinical trial.

Engage Spiral early in your planning and set your clinical trial up for maximum success.

Our randomisation methods

Mitigate bias and create credible, comparable treatment groups—in real-time.

  • Simple

    Participants are randomly assigned to a treatment or control group without constraints.

  • Block

    Participants are randomised in blocks to ensure equal group sizes.

  • Stratified

    Participants are grouped based on specific characteristics and then randomised within each stratum to ensure these characteristics are evenly distributed across the groups.

  • Permuted Block

    Where the order of assignments within the blocks is randomised to reduce predictability.

  • Cluster

    Where entire groups are randomised rather than individual participants, all cluster participants receive the same intervention. Cluster cross-over trials randomly re-assign the clusters at set time points.

  • Adaptive

    Where the probability of assignment to a particular group is adjusted as the trial progresses, often based on accumulating data such as response rates. 

  • Unequal

    Instead of a 1:1 ratio, participants might be randomised in unequal proportions (e.g., 2:1 or 3:1) between groups.

“At Spiral, we have become industry experts in helping our clients choose the type of randomisation they need – a crucial part of the trial process to achieve the best possible outcome.”

“We are working with novel clinical trials which span several years, and we need to operate at the leading edge of technological capabilities.”

Audrey Shearer, Founder & CEO, Spiral Software.

Engage early
for optimal results

Engaging with Spiral early can make all the difference in understanding the amount of resource required, important regulatory considerations, and the proposed methodologies to be used. This means novel clinical trials can get off the ground more quickly, which means life-changing medical interventions are one step closer.
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