- Fluid resuscitation is a fundamental component of the management of critically ill patients and the choice of fluid is a longstanding issue of debate
- Worldwide, 0.9% saline (”normal saline”) has traditionally been the most widely used resuscitation fluid, however its use is increasingly challenged by emerging evidence that its high chloride content may have clinically important adverse effects
- Use of balanced crystalloid solutions such as Plasma-Lyte 148® may be associated with decreased mortality and decreased risk of acute kidney injury
Primary: To determine whether fluid resuscitation and therapy with a “balanced” crystalloid solution (Plasma-Lyte 148®) decreases 90-day mortality in critically ill patients requiring fluid resuscitation when compared with the same treatment using normal saline.
- the study is prospective, multi-centre, parallel group, concealed, blinded, randomised, controlled trial
- PLUS will compare two approaches to fluid resuscitation in critically ill adults in the ICU
- the study will enrol 8,800 patients in ICUs in Australia and New Zealand