TARGET – The Augmented versus Routine approach to Giving Energy Trial. TARGET is a 4,000 patient, multicentre, double-blinded, randomised, controlled, parallel-group, phase III clinical trial. The primary aim of the study is to determine if augmentation of calorie delivery using energy dense enteral nutrition in mechanically ventilated patients improves 90 day survival when compared to routine care. A secondary aim is to determine if augmentation of calorie delivery using energy dense enteral nutrition in mechanically ventilated patients improved functional outcomes at 180 days when compared to routine care. Eligible patients will be randomised 1:1 to receive TARGET protocol enteral nutrition (EN) formulation of either 1 kcal/ml or 1.5 kcal/ml. Protein content in both TARGET protocol EN formulations will be similar.
TARGET protocol EN will be administered for up to 28 days during the ICU stay.